Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | AGER | Q15109 | 1/20 | 0.46 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | DHODH | Q02127 | 2/20 | 0.40 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.39 |
| ▸ | MYC | P01106 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30751959 | 0.84 | MAP2K1 (0.50) | KDM4ETDP1ALDH1A1L3MBTL1TSHR | |
| SCHEMBL270419 | 0.77 | KDM4E (1.00) | KDM4ETDP1ALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL29517274 | 0.77 | KDM4E (0.44) | KDM4ETDP1ALDH1A1L3MBTL1MAPT | |
| SCHEMBL28291927 | 0.77 | KDM4E (0.69) | KDM4ETDP1ALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL31122355 | 0.77 | ALDH1A1 (0.43) | KDM4ETDP1ALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL31092004 | 0.76 | RAB9A (0.45) | KDM4EALDH1A1L3MBTL1CYP3A4MAPT | |
| SCHEMBL11471190 | 0.76 | RAB9A (0.45) | KDM4EALDH1A1L3MBTL1CYP3A4MAPT | |
| SCHEMBL30639818 | 0.75 | KDM4E (0.95) | KDM4ETDP1ALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL30639802 | 0.75 | KDM4E (0.95) | KDM4ETDP1ALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL29723448 | 0.75 | KDM4E (0.95) | KDM4ETDP1ALDH1A1NPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117295724-A | LPA receptor antagonists and uses thereof | 吉利德科学公司 | 2023-12-26 | — | — | CN | disclosed |
| US-5604239-A | GASTROINTESTINAL AND PSYCHOLOGICAL DISORDERS | G. D. SEARLE & CO. (US) | 1997-02-18 | — | — | US | disclosed |
| US-5591749-A | ANXIOLYTIC AND ANTIDEPRESSANT AGENTS; GASTROINTESTINAL AND PSYCHOLOGICAL DISORDERS | G. D. SEARLE & CO. (US) | 1997-01-07 | — | — | US | disclosed |
| US-5434161-A | FOR TREATING ANXIETY, PSYCHOSES, DEPRESSION OR GASTROINTESTINAL MOTILITY | G. D. SEARLE & CO. (US) | 1995-07-18 | — | — | US | disclosed |
| EP-0530353-A1 | NEW IMIDAZOPYRIDINES AS SEROTONERGIC 5-HT 3? ANTAGONISTS | G.D. SEARLE & CO. (US) | 1993-03-10 | — | — | EP | disclosed |
| EP-0504679-A1 | New imidazopyridines as serotonergic 5-HT3 antagonists | G.D. Searle & Co. (US) | 1992-09-23 | — | — | EP | disclosed |
| WO-1992015593-A1 | NEW IMIDAZOPYRIDINES AS SEROTONERGIC 5-HT3 ANTAGONISTS | G.D. SEARLE & CO. (US) | 1992-09-17 | — | — | WO | disclosed |