Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7359845 | 1.00 | GLA (0.49) | GLATSHRRXFP1HTR4HTR1A | |
| SCHEMBL30036140 | 0.79 | HTR3A (0.69) | HTR4HTR1AADRA2CACHEPTGS1 | |
| SCHEMBL7365710 | 0.79 | HTR3A (0.69) | HTR4HTR1AADRA2CACHEPTGS1 | |
| SCHEMBL7434367 | 0.79 | HTR3A (0.69) | HTR4HTR1AADRA2CACHEPTGS1 | |
| Hydrochloric Acid SCHEMBL8786092 | 0.78 | HTR3A (0.68) | HTR4HTR1AADRA2CACHEPTGS1 | |
| SCHEMBL8497978 | 0.77 | HTR4 (0.53) | HTR4HTR1AADRA2CACHEPTGS1 | |
| SCHEMBL8497984 | 0.77 | HTR4 (0.53) | HTR4HTR1AADRA2CACHEPTGS1 | |
| SCHEMBL6670572 | 0.76 | HTR3A (0.62) | HTR4HTR1AADRA2CACHEPTGS1 | |
| SCHEMBL8499980 | 0.76 | HTR4 (0.46) | HTR4HTR1AADRA2CACHEPTGS1 | |
| SCHEMBL27360404 | 0.76 | HTR4 (0.50) | HTR4HTR1AADRA2CACHEPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0766680-A1 | SUBSTITUTED DIHYDROBENZOFURAN DERIVATIVES AS 5-HT 4 AGONISTS | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-04-09 | — | — | EP | disclosed |
| WO-1996033186-A1 | SUBSTITUTED DIHYDROBENZOFURAN DERIVATIVES AS 5-HT4 AGONISTS | PHARMACIA & UPJOHN S.P.A. (IT) | 1996-10-24 | — | — | WO | disclosed |