Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 8/20 | 0.66 |
| ▸ | METAP1 | P53582 | 7/20 | 0.66 |
| ▸ | CTSD | P07339 | 6/20 | 0.58 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7352224 | 0.99 | METAP2 (0.64) | METAP2METAP1CTSDEPHX1SCN9A | |
| SCHEMBL7361134 | 0.88 | METAP2 (0.64) | METAP2METAP1CTSDSCN9A | |
| Hydrochloric Acid SCHEMBL7358295 | 0.87 | METAP2 (0.63) | METAP2METAP1CTSDSCN9A | |
| SCHEMBL7351803 | 0.87 | METAP2 (0.69) | METAP2METAP1CTSD | |
| Hydrochloric Acid SCHEMBL7355716 | 0.86 | METAP2 (0.68) | METAP2METAP1CTSD | |
| SCHEMBL7351699 | 0.85 | METAP2 (0.66) | METAP2METAP1CTSDEPHX1 | |
| SCHEMBL7356284 | 0.84 | METAP2 (0.61) | METAP2METAP1 | |
| Hydrochloric Acid SCHEMBL7350513 | 0.83 | METAP2 (0.60) | METAP2METAP1 | |
| SCHEMBL7360924 | 0.82 | METAP2 (0.49) | METAP2METAP1CTSDEPHX1SCN9A | |
| SCHEMBL6480057 | 0.82 | METAP2 (0.69) | METAP2METAP1CTSDEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242494-B1 | ANGIOGENESIS INHIBITORS, ANTITUMOR AGENTS, DIABETIC RETINOPATHY, AND ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES | 2001-06-05 | — | — | US | claimed |
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | claimed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | claimed |
| US-6242494-B1 | ANGIOGENESIS INHIBITORS, ANTITUMOR AGENTS, DIABETIC RETINOPATHY, AND ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES | 2001-06-05 | — | — | US | disclosed |
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | disclosed |