Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 10/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 2/20 | 0.40 |
| ▸ | CASP7 | P55210 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7369809 | 0.90 | NPC1 (0.36) | NPC1POLBPTK2BALDH1A1RAB9A | |
| SCHEMBL10040047 | 0.73 | POLB (0.74) | NPC1POLBPTK2BALDH1A1RAB9A | |
| SCHEMBL7365111 | 0.71 | PDE5A (0.46) | PDE5ANPC1POLBPTK2BALDH1A1 | |
| SCHEMBL22033267 | 0.70 | TLR8 (0.56) | PDE5ANPC1POLBALDH1A1RAB9A | |
| SCHEMBL10438816 | 0.67 | HTR7 (0.53) | PDE5AALDH1A1RAB9AUSP2CASP1 | |
| SCHEMBL18486482 | 0.67 | POLB (0.59) | NPC1POLBPTK2BALDH1A1RAB9A | |
| SCHEMBL28131881 | 0.67 | PDE5A (0.52) | PDE5AALDH1A1USP2CASP1CASP7 | |
| SCHEMBL11779185 | 0.66 | POLB (0.77) | NPC1POLBPTK2BALDH1A1RAB9A | |
| SCHEMBL7723344 | 0.66 | PDE5A (0.58) | PDE5ANPC1POLBALDH1A1RAB9A | |
| SCHEMBL14988232 | 0.65 | PDE5A (0.47) | PDE5APOLBALDH1A1USP2CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0613467-A1 | 2-PYRIDINOL DERIVATIVES AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1994-09-07 | — | — | EP | disclosed |
| WO-1993010093-A1 | 2-PYRIDINOL DERIVATIVES AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1993-05-27 | — | — | WO | disclosed |