Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 10/20 | 0.35 |
| ▸ | PDCD1LG2 | Q9BQ51 | 9/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | PTPRC | P08575 | 1/20 | 0.34 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | PTPRB | P23467 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7360482 | 0.90 | PDE5A (0.42) | NPC1POLBPTK2BALDH1A1RAB9A | |
| SCHEMBL7365834 | 0.73 | FFAR4 (0.39) | NPC1POLBPTK2BFFAR4ALDH1A1 | |
| SCHEMBL10040047 | 0.68 | POLB (0.74) | NPC1POLBPTK2BALDH1A1RAB9A | |
| SCHEMBL8557526 | 0.65 | LMNA (0.62) | NPC1POLBALDH1A1RAB9A | |
| SCHEMBL10438817 | 0.64 | ADRB2 (0.51) | FFAR4ALDH1A1RAB9A | |
| SCHEMBL7365111 | 0.64 | PDE5A (0.46) | NPC1POLBPTK2BALDH1A1RAB9A | |
| SCHEMBL19056885 | 0.63 | CYP1A2 (0.53) | FFAR4ALDH1A1 | |
| SCHEMBL18486482 | 0.62 | POLB (0.59) | NPC1POLBPTK2BALDH1A1RAB9A | |
| SCHEMBL10756351 | 0.62 | CA1 (0.47) | NPC1ALDH1A1PTPN1 | |
| SCHEMBL7367919 | 0.62 | MERTK (0.38) | NPC1POLBPTK2BALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0613467-A1 | 2-PYRIDINOL DERIVATIVES AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1994-09-07 | — | — | EP | disclosed |
| WO-1993010093-A1 | 2-PYRIDINOL DERIVATIVES AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1993-05-27 | — | — | WO | disclosed |