Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 9/20 | 0.58 |
| ▸ | PDE4A | P27815 | 5/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | GLA | P06280 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9207457 | 0.86 | ADRA1D (0.54) | PDE5AADRA1DADRA1AADRA1BCYP1A2 | |
| SCHEMBL30090606 | 0.85 | SYK (0.46) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL30090454 | 0.85 | CYP11B1 (0.47) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29143257 | 0.83 | PDE5A (0.52) | PDE5AADRA1DADRA1AADRA1BCYP1A2 | |
| SCHEMBL30090598 | 0.81 | PDE5A (0.53) | PDE5AADRA1DADRA1AADRA1BCYP1A2 | |
| SCHEMBL10438816 | 0.81 | HTR7 (0.53) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL30090597 | 0.79 | PDE5A (0.48) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10801186 | 0.79 | ADRA1A (0.54) | PDE5AADRA1DADRA1AADRA1BCYP1A2 | |
| SCHEMBL2039527 | 0.78 | SMN1; SMN2 (0.62) | PDE5AADRA1DADRA1AADRA1BCYP1A2 | |
| SCHEMBL29496935 | 0.78 | SMN1; SMN2 (0.62) | PDE5AADRA1DADRA1AADRA1BCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6391885-B1 | CONTROLLING APOPTOSIS IN AUTOIMMUNE DISEASE | CELL PATHWAYS, INC. | 2002-05-21 | — | — | US | disclosed |