Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 4/20 | 0.50 |
| ▸ | MMP3 | P08254 | 9/20 | 0.39 |
| ▸ | MMP1 | P03956 | 7/20 | 0.39 |
| ▸ | MMP9 | P14780 | 4/20 | 0.39 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | BIRC2 | Q13490 | 2/20 | 0.35 |
| ▸ | UGCG | Q16739 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8507829 | 0.83 | MMP8 (0.62) | MMP8MMP3MMP1MMP9PLA2G10 | |
| SCHEMBL8507843 | 0.81 | UGCG (0.45) | MMP8MMP3MMP1MMP2UGCG | |
| SCHEMBL8509536 | 0.80 | MMP8 (0.47) | MMP8MMP3MMP1MMP9MMP2 | |
| SCHEMBL8509043 | 0.76 | UGCG (0.51) | MMP8MMP3MMP1MMP9MMP2 | |
| SCHEMBL7923582 | 0.74 | UGCG (0.55) | PLA2G10ALDH1A1L3MBTL1UGCG | |
| SCHEMBL13493025 | 0.74 | UGCG (0.55) | PLA2G10ALDH1A1L3MBTL1UGCG | |
| SCHEMBL20382547 | 0.69 | UGCG (0.43) | PLA2G10ALDH1A1L3MBTL1UGCG | |
| SCHEMBL7360512 | 0.67 | L3MBTL1 (0.35) | MMP8MMP3MMP1MMP9ALDH1A1 | |
| SCHEMBL20273119 | 0.67 | PLA2G10 (0.50) | MMP8MMP3MMP9PLA2G10BIRC2 | |
| SCHEMBL32681947 | 0.66 | MMP8 (0.54) | MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1009736-A1 | MALONIC ACID BASED MATRIX METALLOPROTEINASE INHIBITORS | Roche Diagnostics GmbH (DE) | 2000-06-21 | — | — | EP | disclosed |
| EP-0911319-A1 | Malonic acid based matrix metalloproteinase inhibitors | Roche Diagnostics GmbH (DE) | 1999-04-28 | — | — | EP | disclosed |
| WO-1999011608-A1 | MALONIC ACID BASED MATRIX METALLOPROTEINASE INHIBITORS | ROCHE DIAGNOSTICS GMBH (DE) | 1999-03-11 | — | — | WO | disclosed |