Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 9/20 | 0.44 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.38 |
| ▸ | P4HB | P07237 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7458452 | 1.00 | KCNH2 (0.44) | KCNH2KCNJ1MEN1KMT2AALDH1A1 | |
| SCHEMBL7361984 | 0.89 | FFAR1 (0.40) | MEN1KMT2AALDH1A1MAPTP4HB | |
| SCHEMBL7361986 | 0.89 | FFAR1 (0.40) | MEN1KMT2AALDH1A1MAPTP4HB | |
| SCHEMBL7362625 | 0.78 | KCNH2 (0.46) | KCNH2KCNJ1MEN1KMT2AALDH1A1 | |
| SCHEMBL7363729 | 0.72 | KCNH2 (0.50) | KCNH2KCNJ1MEN1KMT2AALDH1A1 | |
| SCHEMBL7360601 | 0.72 | KCNH2 (0.44) | KCNH2KCNJ1MEN1KMT2AALDH1A1 | |
| SCHEMBL7363865 | 0.72 | KCNH2 (0.47) | KCNH2KCNJ1MEN1KMT2AALDH1A1 | |
| SCHEMBL7462970 | 0.72 | KCNH2 (0.43) | KCNH2KCNJ1ALDH1A1MAPTMAOA | |
| SCHEMBL7362630 | 0.71 | KCNH2 (0.47) | KCNH2KCNJ1CDC25C | |
| SCHEMBL7368633 | 0.71 | NR1H4 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892780-B1 | M-AMIDINO PHENYL ANALOGS AS FACTOR Xa INHIBITORS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2002-11-20 | — | — | EP | disclosed |
| EP-0892780-A1 | M-AMIDINO PHENYL ANALOGS AS FACTOR Xa INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997030971-A1 | M-AMIDINO PHENYL ANALOGS AS FACTOR Xa INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-08-28 | — | — | WO | disclosed |