Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 10/20 | 0.79 |
| ▸ | MMP2 | P08253 | 11/20 | 0.63 |
| ▸ | MMP9 | P14780 | 11/20 | 0.63 |
| ▸ | MMP1 | P03956 | 10/20 | 0.59 |
| ▸ | MMP3 | P08254 | 1/20 | 0.49 |
| ▸ | MMP7 | P09237 | 1/20 | 0.49 |
| ▸ | MMP8 | P22894 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | MMP14 | P50281 | 1/20 | 0.49 |
| ▸ | MMP15 | P51511 | 1/20 | 0.49 |
| ▸ | MMP16 | P51512 | 1/20 | 0.49 |
| ▸ | ADAM33 | Q9BZ11 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6627729 | 0.88 | ADAM17 (1.00) | ADAM17MMP2MMP9MMP1MMP3 | |
| SCHEMBL7352992 | 0.80 | MMP2 (0.66) | ADAM17MMP2MMP9MMP1MMP3 | |
| SCHEMBL6628455 | 0.78 | MMP9 (1.00) | ADAM17MMP2MMP9MMP1MMP3 | |
| SCHEMBL7359520 | 0.77 | ADAM17 (0.76) | ADAM17MMP2MMP9MMP1MMP3 | |
| SCHEMBL7352853 | 0.77 | ADAM17 (0.62) | ADAM17MMP2MMP9MMP1MMP3 | |
| SCHEMBL6626561 | 0.77 | ADAM17 (0.80) | ADAM17MMP2MMP9MMP1MMP3 | |
| SCHEMBL21823203 | 0.77 | ADAM17 (0.81) | ADAM17MMP2MMP9MMP1MMP3 | |
| SCHEMBL7355036 | 0.77 | MMP2 (0.74) | ADAM17MMP2MMP9MMP1MMP3 | |
| SCHEMBL6628975 | 0.75 | MMP2 (0.79) | ADAM17MMP2MMP9MMP1MMP3 | |
| SCHEMBL13274077 | 0.74 | MMP2 (1.00) | ADAM17MMP2MMP9MMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027332-A1 | NOVEL LACTAM METALLOPROTEASE INHIBITORS | Du Pont Pharmaceuticals Company (US) | 2000-08-16 | — | — | EP | disclosed |
| WO-1999018074-A1 | NOVEL LACTAM METALLOPROTEASE INHIBITORS | Britol-Myers Squibb Pharma Company (US) | 1999-04-15 | — | — | WO | disclosed |