Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | TPMT | P51580 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6775493 | 0.79 | HSD17B10 (0.46) | KDM4EPOLBGAAALDH1A1HPGD | |
| SCHEMBL7358999 | 0.79 | KDM4E (0.44) | KDM4EPOLBGAAALDH1A1HPGD | |
| SCHEMBL8569535 | 0.78 | KDM4E (0.43) | KDM4EGAAHSP90AA1SLC6A3ALDH1A1 | |
| SCHEMBL6771563 | 0.78 | KDM4E (0.58) | KDM4EPOLBGAAALDH1A1GLA | |
| SCHEMBL24611020 | 0.76 | ALDH1A1 (0.43) | KDM4EPOLBGAASLC6A3ALDH1A1 | |
| SCHEMBL7356591 | 0.76 | GAA (0.63) | GAAALDH1A1GLAHTR4 | |
| SCHEMBL7351281 | 0.74 | HTR4 (0.48) | KDM4ESLC6A3ALDH1A1ACHEHTR4 | |
| SCHEMBL8569184 | 0.73 | GAA (0.44) | KDM4EGAAHSP90AA1SLC6A3ALDH1A1 | |
| SCHEMBL21050898 | 0.73 | MEN1 (0.46) | KDM4EPOLBGAAHSP90AA1SLC6A3 | |
| SCHEMBL31419843 | 0.72 | ALDH1A1 (0.53) | KDM4EGAASLC6A3ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0700383-B1 | NOVEL 1-PHENYLALKANONE 5-HT 4? RECEPTOR LIGANDS | SYNTEX INC (US) | 1998-09-23 | — | — | EP | disclosed |
| US-5763458-A | NERVOUS SYSTEM DISORDERS, ANXIETY, ANTIDEPRESSANTS AND COGNITION ACTIVATORS | SYNTEX (U.S.A.) INC. (US) | 1998-06-09 | — | — | US | disclosed |
| WO-1994027965-A1 | NOVEL 1-PHENYLALKANONE 5-HT4 RECEPTOR LIGANDS | SYNTEX (U.S.A.) INC. (US) | 1994-12-08 | — | — | WO | disclosed |