Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 5/20 | 0.61 |
| ▸ | METAP1 | P53582 | 3/20 | 0.49 |
| ▸ | REN | P00797 | 2/20 | 0.49 |
| ▸ | CPB2 | Q96IY4 | 11/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NMT2 | O60551 | 1/20 | 0.43 |
| ▸ | NMT1 | P30419 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7355867 | 1.00 | METAP2 (0.61) | METAP2METAP1RENCPB2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7358976 | 0.99 | METAP2 (0.60) | METAP2METAP1RENCPB2ALDH1A1 | |
| SCHEMBL7351392 | 0.88 | METAP2 (0.59) | METAP2METAP1RENALDH1A1KMT2A | |
| SCHEMBL29476600 | 0.87 | CPB2 (0.52) | METAP2CPB2ALDH1A1KMT2ANMT2 | |
| SCHEMBL7357202 | 0.83 | METAP2 (0.54) | METAP2METAP1RENCPB2 | |
| SCHEMBL7353581 | 0.83 | METAP2 (0.54) | METAP2METAP1RENCPB2 | |
| SCHEMBL11407267 | 0.82 | METAP2 (0.51) | METAP2METAP1RENCPB2ALDH1A1 | |
| SCHEMBL11407261 | 0.82 | METAP2 (0.51) | METAP2METAP1RENCPB2ALDH1A1 | |
| SCHEMBL7361186 | 0.82 | METAP2 (0.51) | METAP2METAP1RENCPB2ALDH1A1 | |
| SCHEMBL7357763 | 0.82 | METAP2 (0.53) | METAP2METAP1RENCPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242494-B1 | ANGIOGENESIS INHIBITORS, ANTITUMOR AGENTS, DIABETIC RETINOPATHY, AND ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES | 2001-06-05 | — | — | US | claimed |
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | claimed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | claimed |