Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.38 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9187239 | 0.79 | CYP2D6 (0.53) | TAAR1MAOASLC6A2SIGMAR1SLC6A4 | |
| SCHEMBL8512221 | 0.79 | TAAR1 (0.50) | TAAR1MAOASLC6A2SIGMAR1SLC6A4 | |
| SCHEMBL21242301 | 0.77 | TAAR1 (0.48) | TAAR1MAOASLC6A2SIGMAR1SLC6A4 | |
| SCHEMBL23934035 | 0.76 | TAAR1 (0.47) | TAAR1MAOASLC6A2SIGMAR1SLC6A4 | |
| SCHEMBL11094964 | 0.73 | MAOA (0.52) | TAAR1MAOASLC6A2SIGMAR1SLC6A4 | |
| SCHEMBL8086703 | 0.73 | MAOA (0.52) | TAAR1MAOASLC6A2SIGMAR1SLC6A4 | |
| SCHEMBL8713206 | 0.73 | EPHX1 (0.61) | TAAR1MAOASLC6A2SIGMAR1SLC6A4 | |
| SCHEMBL11097972 | 0.73 | MAOA (0.52) | TAAR1MAOASLC6A2SIGMAR1SLC6A4 | |
| SCHEMBL19628486 | 0.73 | TAAR1 (0.52) | TAAR1MAOASLC6A2SIGMAR1SLC6A4 | |
| SCHEMBL9329236 | 0.73 | MAOA (0.52) | TAAR1MAOASLC6A2SIGMAR1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0722321-A4 | SULFOXIMINE AND SULFODIIMINE MATRIX METALLOPROTEINASE INHIBITORS | UNIV FLORIDA STATE (US) | 1998-04-15 | — | — | EP | disclosed |
| EP-0722321-A1 | SULFOXIMINE AND SULFODIIMINE MATRIX METALLOPROTEINASE INHIBITORS | FLORIDA STATE UNIVERSITY (US) | 1996-07-24 | — | — | EP | disclosed |
| US-5470834-A | Metalloproteinase enzyme inhibitors for arthritis, rheumatism and cancers | FLORIDA STATE UNIVERSITY (US) | 1995-11-28 | — | — | US | disclosed |
| WO-1995009620-A1 | SULFOXIMINE AND SULFODIIMINE MATRIX METALLOPROTEINASE INHIBITORS | FLORIDA STATE UNIVERSITY (US) | 1995-04-13 | — | — | WO | disclosed |