Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
| ▸ | SHBG | P04278 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2990994 | 0.83 | METAP1 (0.44) | METAP1CYP1A2SIGMAR1HPGDALDH1A1 | |
| SCHEMBL2999758 | 0.82 | EPHX1 (0.40) | METAP1CYP1A2SIGMAR1HPGDALDH1A1 | |
| SCHEMBL7336691 | 0.77 | METAP1 (0.45) | METAP1CYP1A2SIGMAR1HPGD | |
| SCHEMBL1443658 | 0.76 | SHBG (0.46) | METAP1CYP1A2SIGMAR1HPGDALDH1A1 | |
| SCHEMBL6877804 | 0.76 | METAP1 (0.39) | METAP1CYP1A2SIGMAR1HPGDALDH1A1 | |
| SCHEMBL9450351 | 0.74 | METAP1 (0.36) | METAP1CYP1A2SIGMAR1 | |
| SCHEMBL15588920 | 0.73 | METAP1 (0.38) | METAP1HPGDALDH1A1EPHX1 | |
| SCHEMBL9655442 | 0.71 | METAP1 (0.30) | METAP1 | |
| SCHEMBL2992784 | 0.70 | EPHX1 (0.48) | METAP1CYP1A2SIGMAR1HPGDALDH1A1 | |
| SCHEMBL2997439 | 0.69 | CYP1A2 (0.34) | METAP1CYP1A2SIGMAR1SHBG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0504888-A1 | 5-Arylheteroarylalkyl-1,3,5-trisubstituted-1,2,4-triazole compounds for treatment of circulatory disorders | G.D. Searle & Co. (US) | 1992-09-23 | — | — | EP | claimed |