SCHEMBL7361696

SCHEMBL7361696

O=C(O)c1cccnc1C(=O)c1cccc(Cl)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.56
KDM4E B2RXH2 2/20 0.56
ALOX15 P16050 2/20 0.56
ALDH1A1 P00352 2/20 0.56
MAPT P10636 2/20 0.56
CYP3A4 P08684 1/20 0.56
TSHR P16473 1/20 0.56
BLM P54132 1/20 0.56
AGER Q15109 1/20 0.56
NPSR1 Q6W5P4 1/20 0.56
KMT2A Q03164 4/20 0.50
MEN1 O00255 3/20 0.50
SMN1; SMN2 Q16637 3/20 0.50
LMNA P02545 2/20 0.50
DHODH Q02127 2/20 0.47
RORB Q92753 1/20 0.46
TDP1 Q9NUW8 1/20 0.45
VNN1 O95497 1/20 0.44
PARP1 P09874 1/20 0.44
RAB9A P51151 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7366851 0.88 ALOX15 (0.56) L3MBTL1KDM4EALOX15ALDH1A1MAPT
SCHEMBL7362970 0.83 MEN1 (0.49) L3MBTL1KDM4EALOX15ALDH1A1MAPT
SCHEMBL9172028 0.83 ALDH1A1 (0.61) L3MBTL1KDM4EALOX15ALDH1A1MAPT
SCHEMBL7347947 0.82 ALDH1A1 (0.69) L3MBTL1KDM4EALOX15ALDH1A1MAPT
SCHEMBL1251352 0.82 ALDH1A1 (0.56) L3MBTL1KDM4EALOX15ALDH1A1MAPT
SCHEMBL7365802 0.82 MAPT (0.56) L3MBTL1KDM4EALOX15ALDH1A1MAPT
SCHEMBL7370711 0.82 POLB (0.63) L3MBTL1KDM4EALOX15ALDH1A1MAPT
SCHEMBL7368545 0.79 ALDH1A1 (0.63) L3MBTL1KDM4EALOX15ALDH1A1MAPT
SCHEMBL7369371 0.79 FOLH1 (0.56) L3MBTL1KDM4EALOX15ALDH1A1MAPT
SCHEMBL9170045 0.79 KDM4E (0.51) L3MBTL1KDM4EALOX15ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0612321-B1 PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY SYNTEX INC (US) 1999-08-25 EP disclosed
US-5716954-A ANTIINFLAMMATORY AGENT, ANTIHISTAMINES, IMMUNOSUPPRESSION,AUTOIMMUNE DISEASES SYNTEX U.S.A. INC. (US) 1998-02-10 US disclosed
US-5405826-A Herbicidal pyridopyridazinones and pyridopyridazinethiones RHONE POULENC AGRICULTURE LIMITED (GB) 1995-04-11 US disclosed
EP-0612321-A1 PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY SYNTEX (U.S.A.) INC. (US) 1994-08-31 EP disclosed
EP-0555957-A1 Pyrido 2,3-d pyridazine derivatives as herbicides RHONE-POULENC AGRICULTURE LTD. (GB) 1993-08-18 EP disclosed
WO-1993007146-A1 BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY SYNTEX (U.S.A.) INC. (US) 1993-04-15 WO disclosed