Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | GRM5 | P41594 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364444 | 0.90 | MEN1 (0.49) | MEN1KMT2AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL7370453 | 0.88 | ALOX15 (0.50) | MEN1KMT2AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL1252335 | 0.84 | PBRM1 (0.45) | KMT2AKDM4EALDH1A1L3MBTL1ALOX15 | |
| SCHEMBL7361925 | 0.84 | TDP1 (0.49) | MEN1KMT2AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL7362471 | 0.84 | PKM (0.49) | MEN1KMT2AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL7361696 | 0.83 | L3MBTL1 (0.56) | MEN1KMT2AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL7364891 | 0.83 | TDP1 (0.56) | KMT2AKDM4EALDH1A1L3MBTL1NPSR1 | |
| SCHEMBL7367891 | 0.80 | MEN1 (0.52) | MEN1KMT2AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL7365348 | 0.80 | KMT2A (0.51) | MEN1KMT2AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL7362977 | 0.80 | ALDH1A1 (0.45) | MEN1KMT2AKDM4EALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-B1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX INC (US) | 1999-08-25 | — | — | EP | disclosed |
| US-5716954-A | ANTIINFLAMMATORY AGENT, ANTIHISTAMINES, IMMUNOSUPPRESSION,AUTOIMMUNE DISEASES | SYNTEX U.S.A. INC. (US) | 1998-02-10 | — | — | US | disclosed |
| US-5466697-A | 8-phenyl-1,6-naphthyridin-5-ones | SYNTEX (U.S.A.) INC. (US) | 1995-11-14 | — | — | US | disclosed |
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |