Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.63 |
| ▸ | MAPT | P10636 | 11/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 8/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2880949 | 0.94 | FDPS (0.75) | FDPSALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL1748837 | 0.93 | FDPS (0.71) | FDPSALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL5111350 | 0.88 | FDPS (0.69) | FDPSALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL7355634 | 0.87 | FDPS (0.71) | FDPSALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL13352265 | 0.87 | FDPS (0.67) | FDPSALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL686103 | 0.87 | FDPS (0.81) | FDPSALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL7661907 | 0.87 | FDPS (0.86) | FDPSALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL16067479 | 0.86 | FDPS (0.74) | FDPSALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL1121628 | 0.85 | FDPS (0.73) | FDPSALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL2821372 | 0.85 | FDPS (0.67) | FDPSALDH1A1MAPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | disclosed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | disclosed |