Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Mirisetron. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | HTR3A | P46098 | 8/20 | 0.55 |
| ▸ | HTR3E | A5X5Y0 | 6/20 | 0.55 |
| ▸ | HTR3B | O95264 | 6/20 | 0.55 |
| ▸ | HTR3D | Q70Z44 | 6/20 | 0.55 |
| ▸ | HTR3C | Q8WXA8 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | CNR1 | P21554 | 2/20 | 0.50 |
| ▸ | CNR2 | P34972 | 2/20 | 0.50 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mirisetron SCHEMBL678308 | 1.00 | KDM4E (0.58) | KDM4EHTR3AHTR3EHTR3BHTR3D | |
| Mirisetron SCHEMBL121862 | 1.00 | KDM4E (0.58) | KDM4EHTR3AHTR3EHTR3BHTR3D | |
| Mirisetron SCHEMBL121861 | 1.00 | KDM4E (0.58) | KDM4EHTR3AHTR3EHTR3BHTR3D | |
| Mirisetron SCHEMBL194840 | 0.94 | KDM4E (0.61) | KDM4EHTR3AHTR3EHTR3BHTR3D | |
| Mirisetron SCHEMBL194841 | 0.94 | KDM4E (0.61) | KDM4EHTR3AHTR3EHTR3BHTR3D | |
| Mirisetron SCHEMBL6695569 | 0.94 | KDM4E (0.61) | KDM4EHTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL9029352 | 0.90 | HTR3A (0.63) | KDM4EHTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL9028258 | 0.81 | HTR3A (0.60) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL9027434 | 0.81 | HTR3A (0.64) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL22416052 | 0.78 | CNR1 (0.57) | HTR3AHTR3EHTR3BHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995001793-A2 | 5-HT-3-ANTAGONISTS AS TOPICAL MEDICAMENTS FOR TREATMENT OF PERIPHERAL DISORDERS ASSOCIATED WITH PAIN | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-01-19 | — | — | WO | disclosed |