Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28065706 | 0.78 | KDM4E (0.43) | KDM4ELMNAHTTMEN1KMT2A | |
| SCHEMBL3463767 | 0.76 | CCR1 (0.33) | KDM4ELMNAMAPTHTTMEN1 | |
| SCHEMBL681786 | 0.74 | NQO2 (0.50) | ALDH1A1MAPTNPSR1MEN1KMT2A | |
| SCHEMBL6585052 | 0.69 | MEN1 (0.40) | KDM4ELMNAALDH1A1MAPTHTT | |
| SCHEMBL4701309 | 0.69 | MBOAT4 (0.36) | KDM4ELMNAMAPTHTTMEN1 | |
| Tetrabuthylammonium SCHEMBL7369591 | 0.68 | KMT2A (0.48) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL6755221 | 0.68 | HPGD (0.34) | KDM4ELMNAALDH1A1MAPTMEN1 | |
| SCHEMBL6509825 | 0.67 | LMNA (0.40) | LMNAMAPT | |
| SCHEMBL17506427 | 0.66 | KMT2A (0.50) | KDM4ELMNAALDH1A1MAPTHTT | |
| SCHEMBL1421106 | 0.66 | SLC6A4 (0.37) | KDM4ELMNAALDH1A1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952832-A1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | Darwin Discovery Limited (GB) | 1999-11-03 | — | — | EP | disclosed |
| WO-1997044036-A1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 1997-11-27 | — | — | WO | disclosed |