SCHEMBL7362191

SCHEMBL7362191

O=C(NC1CN2CCC1CC2)c1cccn2ccnc12

nearest known ligand 0.67

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HTR3A P46098 1/20 0.67
CHRNA7 P36544 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7361204 0.86 HTR3A (0.55) HTR3A
SCHEMBL7362682 0.81 HTR3A (1.00) HTR3ACHRNA7
Hydrochloric Acid SCHEMBL7363031 0.80 HTR3A (0.98) HTR3ACHRNA7
SCHEMBL30010027 0.77 HSD11B1 (0.61) HTR3ACHRNA7
SCHEMBL5267272 0.76 HTR3A (0.63) HTR3ACHRNA7
SCHEMBL5270359 0.76 HTR3A (0.63) HTR3ACHRNA7
SCHEMBL5917863 0.76 CHRNA7 (0.67) HTR3ACHRNA7
SCHEMBL6101482 0.76
SCHEMBL2229398 0.75 HTR3A (0.56) HTR3ACHRNA7
SCHEMBL2229393 0.75 HTR3A (0.56) HTR3ACHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0530353-A1 NEW IMIDAZOPYRIDINES AS SEROTONERGIC 5-HT 3? ANTAGONISTS G.D. SEARLE & CO. (US) 1993-03-10 EP claimed
EP-0504679-A1 New imidazopyridines as serotonergic 5-HT3 antagonists G.D. Searle & Co. (US) 1992-09-23 EP claimed
WO-1992015593-A1 NEW IMIDAZOPYRIDINES AS SEROTONERGIC 5-HT3 ANTAGONISTS G.D. SEARLE & CO. (US) 1992-09-17 WO claimed
US-5604239-A GASTROINTESTINAL AND PSYCHOLOGICAL DISORDERS G. D. SEARLE & CO. (US) 1997-02-18 US disclosed
US-5591749-A ANXIOLYTIC AND ANTIDEPRESSANT AGENTS; GASTROINTESTINAL AND PSYCHOLOGICAL DISORDERS G. D. SEARLE & CO. (US) 1997-01-07 US disclosed
US-5434161-A FOR TREATING ANXIETY, PSYCHOSES, DEPRESSION OR GASTROINTESTINAL MOTILITY G. D. SEARLE & CO. (US) 1995-07-18 US disclosed
EP-0530353-A1 NEW IMIDAZOPYRIDINES AS SEROTONERGIC 5-HT 3? ANTAGONISTS G.D. SEARLE & CO. (US) 1993-03-10 EP disclosed
EP-0504679-A1 New imidazopyridines as serotonergic 5-HT3 antagonists G.D. Searle & Co. (US) 1992-09-23 EP disclosed
WO-1992015593-A1 NEW IMIDAZOPYRIDINES AS SEROTONERGIC 5-HT3 ANTAGONISTS G.D. SEARLE & CO. (US) 1992-09-17 WO disclosed