Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.48 |
| ▸ | NCS1 | P62166 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6467368 | 0.81 | MAOB (0.49) | HPGDALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL17287819 | 0.79 | CSNK1D (0.67) | HPGDALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5184333 | 0.79 | CSNK1D (0.67) | HPGDALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5974074 | 0.75 | KDM4E (0.52) | HPGDALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6802148 | 0.74 | NPC1 (0.57) | HPGDALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL369480 | 0.73 | ALDH1A1 (0.62) | HPGDALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7975064 | 0.73 | SMN1; SMN2 (0.59) | HPGDALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11989035 | 0.72 | ALOX15 (0.65) | HPGDALDH1A1MEN1KMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3492104 | 0.72 | ALDH1A1 (0.60) | HPGDALDH1A1MEN1KMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5009760 | 0.72 | ALDH1A1 (0.60) | HPGDALDH1A1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1159273-A1 | COMPOUNDS USEFUL AS REVERSIBLE INHIBITORS OF CATHEPSIN S | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000051998-A1 | COMPOUNDS USEFUL AS REVERSIBLE INHIBITORS OF CATHEPSIN S | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2000-09-08 | — | — | WO | disclosed |