Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT3 | O60678 | 1/20 | 0.42 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.42 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.42 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.42 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27365590 | 0.91 | PRMT3 (0.36) | PRMT3CARM1PRMT6PRMT1PRMT8 | |
| SCHEMBL47061 | 0.89 | PRMT3 (0.34) | PRMT3CARM1PRMT6PRMT1PRMT8 | |
| SCHEMBL3318180 | 0.89 | PRMT3 (0.37) | PRMT3CARM1PRMT6PRMT1PRMT8 | |
| SCHEMBL22961939 | 0.84 | PRMT3 (0.32) | PRMT3CARM1PRMT6PRMT1PRMT8 | |
| SCHEMBL19704692 | 0.82 | CA2 (0.35) | CA2 | |
| SCHEMBL562717 | 0.81 | PRMT3 (0.59) | PRMT3CARM1PRMT6PRMT1PRMT8 | |
| SCHEMBL1292539 | 0.81 | PIK3CD (0.43) | PIK3CDMEN1KMT2ACA2 | |
| SCHEMBL25792518 | 0.79 | PRMT3 (0.33) | PRMT3CARM1PRMT6PRMT1PRMT8 | |
| SCHEMBL14996455 | 0.79 | — | — | |
| SCHEMBL21540184 | 0.79 | EPHX1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5348953-A | Elastase inhibitor | MERCK & CO., INC. (US) | 1994-09-20 | — | — | US | disclosed |
| WO-1994013636-A1 | NEW SUBSTITUTED AZETIDINONES AS ANTI-INFLAMMATORY AND ANTIDEGENERATIVE AGENTS | MERCK & CO., INC. (US) | 1994-06-23 | — | — | WO | disclosed |
| EP-0525973-A2 | Substituted azetidinones as anti-inflammatory and antidegenerative agents | MERCK & CO. INC. (US) | 1993-02-03 | — | — | EP | disclosed |
| WO-1993000332-A1 | SUBSTITUTED AZETIDINONES AS ANTI-INFLAMMATORY AND ANTIDEGENERATIVE AGENTS | MERCK & CO., INC. (US) | 1993-01-07 | — | — | WO | disclosed |