Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 5/20 | 0.49 |
| ▸ | CDK2 | P24941 | 5/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.49 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 4/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCND2 | P30279 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7663415 | 0.96 | PDGFRA (0.47) | CCNE1CDK2PDGFRACTSLKCNH3 | |
| SCHEMBL7363934 | 0.93 | CCNE1 (0.52) | CCNE1CDK2PDGFRACTSLCDK1 | |
| SCHEMBL7670599 | 0.91 | CTSL (0.42) | CCNE1CDK2PDGFRACTSLKCNH3 | |
| SCHEMBL7672226 | 0.88 | CDK1 (0.45) | CCNE1CDK2PDGFRACTSLKCNH3 | |
| SCHEMBL7661496 | 0.87 | CTSL (0.41) | CCNE1CDK2PDGFRACTSLKCNH3 | |
| SCHEMBL7670076 | 0.86 | PDGFRA (0.47) | CCNE1CDK2PDGFRACTSLKCNH3 | |
| SCHEMBL7358873 | 0.85 | CTSL (0.46) | CCNE1CDK2PDGFRACTSLKCNH3 | |
| SCHEMBL7661515 | 0.84 | CCNE1 (0.54) | CCNE1CDK2PDGFRACTSLCDK1 | |
| SCHEMBL7668634 | 0.84 | CCNE1 (0.54) | CCNE1CDK2PDGFRACTSLCDK1 | |
| SCHEMBL7667654 | 0.83 | CCNE1 (0.53) | CCNE1CDK2PDGFRACTSLKCNH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | claimed |
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | disclosed |
| WO-2000037471-A1 | 2-AMINO-9-ALKYLPURINES: GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 2000-06-29 | — | — | WO | disclosed |