Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 3/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.47 |
| ▸ | CDK2 | P24941 | 3/20 | 0.47 |
| ▸ | CDK1 | P06493 | 9/20 | 0.44 |
| ▸ | KCNH3 | Q9ULD8 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CASP1 | P29466 | 3/20 | 0.41 |
| ▸ | CASP7 | P55210 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | HBB | P68871 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7663415 | 0.90 | PDGFRA (0.47) | PDGFRACCNE1CDK2CDK1KCNH3 | |
| SCHEMBL7358873 | 0.87 | CTSL (0.46) | PDGFRACCNE1CDK2CDK1KCNH3 | |
| SCHEMBL7661496 | 0.86 | CTSL (0.41) | PDGFRACCNE1CDK2CDK1KCNH3 | |
| SCHEMBL7362489 | 0.86 | CCNE1 (0.49) | PDGFRACCNE1CDK2CDK1KCNH3 | |
| SCHEMBL7670599 | 0.85 | CTSL (0.42) | PDGFRACCNE1CDK2CDK1KCNH3 | |
| SCHEMBL7672226 | 0.84 | CDK1 (0.45) | PDGFRACCNE1CDK2CDK1KCNH3 | |
| SCHEMBL7363934 | 0.83 | CCNE1 (0.52) | PDGFRACCNE1CDK2CDK1CTSL | |
| SCHEMBL7670226 | 0.82 | CDK1 (0.39) | PDGFRACCNE1CDK2CDK1KCNH3 | |
| SCHEMBL7674300 | 0.82 | CTSL (0.50) | PDGFRACCNE1CDK2CDK1CTSL | |
| SCHEMBL7357728 | 0.81 | CTSL (0.43) | PDGFRACCNE1CDK2CDK1KCNH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | claimed |
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | disclosed |