Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.41 |
| ▸ | CDK2 | P24941 | 5/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7663415 | 0.91 | PDGFRA (0.47) | CTSLCDK1PDGFRACCNE1CDK2 | |
| SCHEMBL7362489 | 0.91 | CCNE1 (0.49) | CTSLCDK1PDGFRACCNE1CDK2 | |
| SCHEMBL7667689 | 0.87 | KCNH3 (0.46) | CTSLCDK1PDGFRACCNE1CDK2 | |
| SCHEMBL7673595 | 0.87 | KDM4E (0.45) | CTSLCDK1KDM4ENFKB1PDGFRA | |
| SCHEMBL7661496 | 0.86 | CTSL (0.41) | CTSLCDK1PDGFRACCNE1CDK2 | |
| SCHEMBL7358873 | 0.86 | CTSL (0.46) | CTSLCDK1PDGFRACCNE1CDK2 | |
| SCHEMBL7672226 | 0.85 | CDK1 (0.45) | CTSLCDK1PDGFRACCNE1CDK2 | |
| SCHEMBL7670076 | 0.85 | PDGFRA (0.47) | CTSLCDK1PDGFRACCNE1CDK2 | |
| SCHEMBL7363934 | 0.84 | CCNE1 (0.52) | CTSLCDK1PDGFRACCNE1CDK2 | |
| SCHEMBL7671239 | 0.83 | PDGFRA (0.43) | CTSLCDK1KDM4EPDGFRACCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | claimed |
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | disclosed |