Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PRCP | P42785 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.33 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | FNTA | P49354 | 1/20 | 0.32 |
| ▸ | FNTB | P49356 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.32 |
| ▸ | TLR2 | O60603 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7402589 | 0.94 | HDAC8 (0.35) | DPP7MEN1KMT2APRCPHDAC3 | |
| SCHEMBL7400406 | 0.85 | HDAC8 (0.35) | DPP7PRCPHDAC3HDAC4HDAC1 | |
| Proline SCHEMBL7401865 | 0.80 | ITGB3 (0.48) | DPP7PRCP | |
| SCHEMBL30835502 | 0.74 | DPP7 (0.58) | DPP7MEN1KMT2APRCPGPR88 | |
| Proline SCHEMBL7406200 | 0.74 | ITGB3 (0.47) | MEN1KMT2A | |
| SCHEMBL7400749 | 0.74 | ITGB3 (0.50) | PRCP | |
| Proline SCHEMBL719217 | 0.72 | PRCP (0.46) | DPP7MEN1KMT2APRCP | |
| Proline SCHEMBL719216 | 0.72 | PRCP (0.46) | DPP7MEN1KMT2APRCP | |
| Norvaline SCHEMBL23125052 | 0.70 | DPP7 (0.43) | DPP7MEN1KMT2APRCPTLR2 | |
| Norvaline SCHEMBL23125050 | 0.70 | DPP7 (0.43) | DPP7MEN1KMT2APRCPTLR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765338-B1 | ARGININE MIMIC DERIVATIVES AS ENZYME INHIBITORS | CORVAS INT INC (US) | 1999-04-21 | — | — | EP | disclosed |
| US-5883107-A | ANTITHROMBOTIC AGENTS | CORVAS INTERNATIONAL, INC. (US) | 1999-03-16 | — | — | US | disclosed |
| EP-0765338-A1 | ARGININE MIMIC DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1997-04-02 | — | — | EP | disclosed |
| WO-1995035312-A1 | ARGININE MIMIC DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1995-12-28 | — | — | WO | disclosed |
| WO-1995028420-A1 | METHIONINE SULFONE AND S-SUBSTITUTED CYSTEINE SULFONE DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1995-10-26 | — | — | WO | disclosed |