Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 16/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 14/20 | 0.48 |
| ▸ | ITGAV | P06756 | 3/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.41 |
| ▸ | PRCP | P42785 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7400749 | 0.94 | ITGB3 (0.50) | ITGB3ITGA2BITGAVCHRM2SLC6A4 | |
| SCHEMBL7405498 | 0.85 | ITGB3 (0.45) | ITGB3ITGA2BITGAVCHRM2SLC6A4 | |
| Proline SCHEMBL7406200 | 0.82 | ITGB3 (0.47) | ITGB3ITGA2BITGAVCHRM2SLC6A4 | |
| SCHEMBL7395698 | 0.82 | ITGB3 (0.47) | ITGB3ITGA2BITGAVCHRM2SLC6A4 | |
| Proline SCHEMBL7362592 | 0.80 | DPP7 (0.39) | DPP7PRCP | |
| SCHEMBL7402072 | 0.76 | ITGB3 (0.48) | ITGB3ITGA2BITGAVCHRM2SLC6A4 | |
| SCHEMBL7402589 | 0.74 | HDAC8 (0.35) | ITGB3ITGA2BDPP7PRCP | |
| Proline SCHEMBL719217 | 0.72 | PRCP (0.46) | DPP7PRCP | |
| Proline SCHEMBL719216 | 0.72 | PRCP (0.46) | DPP7PRCP | |
| SCHEMBL31522342 | 0.71 | ITGB3 (0.51) | ITGB3ITGA2BITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765340-B1 | METHIONINE SULFONE AND S-SUBSTITUTED CYSTEINE SULFONE DERIVATIVES AS ENZYME INHIBITORS | CORVAS INT INC (US) | 2000-08-30 | — | — | EP | disclosed |
| US-5776927-A | THROMBIN INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1998-07-07 | — | — | US | disclosed |
| US-5681844-A | ANTITHROMBOTIC AGENTS, ANTICOAGULANTS | CORVAS INTERNATIONAL, INC. (US) | 1997-10-28 | — | — | US | disclosed |
| US-5658939-A | PREVENTION THROMBOSIS IN MAMMALS | CORVAS INTERNATIONAL INC. (US) | 1997-08-19 | — | — | US | disclosed |
| US-5646165-A | ANTITHROMBOTIC AGENTS | CORVAS INTERNATIONAL, INC. (US) | 1997-07-08 | — | — | US | disclosed |
| EP-0765340-A1 | METHIONINE SULFONE AND S-SUBSTITUTED CYSTEINE SULFONE DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1997-04-02 | — | — | EP | disclosed |
| WO-1995028420-A1 | METHIONINE SULFONE AND S-SUBSTITUTED CYSTEINE SULFONE DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1995-10-26 | — | — | WO | disclosed |