Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 11/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 9/20 | 0.47 |
| ▸ | ITGAV | P06756 | 3/20 | 0.43 |
| ▸ | CTSC | P53634 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7402072 | 0.95 | ITGB3 (0.48) | ITGB3ITGA2BITGAVSLC1A3SLC1A2 | |
| SCHEMBL7401816 | 0.84 | ITGB3 (0.47) | ITGB3ITGA2BITGAVSLC1A3SLC1A2 | |
| SCHEMBL7357439 | 0.84 | SLC1A3 (0.52) | ITGB3ITGA2BITGAVSLC1A3SLC1A2 | |
| Proline SCHEMBL7401865 | 0.82 | ITGB3 (0.48) | ITGB3ITGA2BITGAVCHRM2SLC6A4 | |
| SCHEMBL7400749 | 0.76 | ITGB3 (0.50) | ITGB3ITGA2BITGAVCHRM2SLC6A4 | |
| Proline SCHEMBL27656898 | 0.76 | CTSC (0.51) | ITGB3ITGA2BCTSCHTR2CHTR2B | |
| SCHEMBL7448261 | 0.74 | ITGB3 (0.52) | ITGB3ITGA2BSLC1A3SLC1A2SLC1A1 | |
| SCHEMBL4058881 | 0.74 | SLC1A3 (0.55) | ITGB3ITGA2BITGAVSLC1A3SLC1A2 | |
| Proline SCHEMBL7362592 | 0.74 | DPP7 (0.39) | MEN1KMT2A | |
| Proline SCHEMBL15676617 | 0.73 | CTSC (0.55) | CTSCHTR2CHTR2BMMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765340-B1 | METHIONINE SULFONE AND S-SUBSTITUTED CYSTEINE SULFONE DERIVATIVES AS ENZYME INHIBITORS | CORVAS INT INC (US) | 2000-08-30 | — | — | EP | disclosed |
| EP-0765340-A1 | METHIONINE SULFONE AND S-SUBSTITUTED CYSTEINE SULFONE DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1997-04-02 | — | — | EP | disclosed |
| WO-1995028420-A1 | METHIONINE SULFONE AND S-SUBSTITUTED CYSTEINE SULFONE DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1995-10-26 | — | — | WO | disclosed |