Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2118060 | 0.95 | CA1 (0.45) | KMT2AKDM4EPDE4DCA1CA2 | |
| SCHEMBL3425983 | 0.84 | MAPT (0.47) | KMT2AKDM4EPDE4DPIM1MEN1 | |
| SCHEMBL847651 | 0.83 | KDM4E (0.65) | KMT2AKDM4EPDE4DPIM1CA1 | |
| SCHEMBL7362665 | 0.82 | KMT2A (0.54) | KMT2AKDM4EPDE4DPIM1CA1 | |
| SCHEMBL7362663 | 0.80 | KDM4E (0.77) | KMT2AKDM4EPDE4DPIM1CA1 | |
| SCHEMBL2116612 | 0.79 | MAPT (0.50) | KMT2AKDM4EMEN1MAPTALDH1A1 | |
| SCHEMBL2944266 | 0.78 | METAP2 (0.40) | KMT2AKDM4EPDE4DMETAP2 | |
| SCHEMBL4701058 | 0.76 | KDM4E (0.56) | KMT2AKDM4EPDE4DCA1CA2 | |
| SCHEMBL2950729 | 0.76 | ALDH1A1 (0.44) | KMT2AKDM4EPDE4DCA1CA2 | |
| SCHEMBL590594 | 0.75 | MTNR1A (0.42) | PDE4DCA1CA2METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250152-A1 | QUINOLINES AS INHIBITORS OF FARNESYL PYROPHOSPHATE SYNTHASE | Novartis AG (CH) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009106586-A1 | QUINOLINES AS INHIBITORS OF FARNESYL PYROPHOSPHATE SYNTHASE | NOVARTIS AG (CH) | 2009-09-03 | — | — | WO | disclosed |