Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | KLK1 | P06870 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5750943 | 0.81 | MEN1 (0.51) | CES2CES1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL8708792 | 0.76 | SMN1; SMN2 (0.52) | CES2CES1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL9669231 | 0.69 | NPC1 (0.43) | CES2CES1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL5678286 | 0.68 | KDM4E (0.53) | HPGDKDM4EPLAUKMT2AMEN1 | |
| SCHEMBL397225 | 0.67 | CES2 (0.60) | CES2CES1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL5678124 | 0.67 | CYP1A2 (0.44) | KDM4EMAPTTSHRALDH1A1CYP3A4 | |
| SCHEMBL1374762 | 0.65 | — | — | |
| SCHEMBL4526053 | 0.65 | CYP11B1 (0.50) | SMN1; SMN2HPGDKDM4EKMT2AMEN1 | |
| SCHEMBL23421115 | 0.65 | PBRM1 (0.53) | SMN1; SMN2KDM4EKMT2AMEN1MAPT | |
| SCHEMBL43058 | 0.64 | ALDH1A1 (0.71) | CES2CES1SMN1; SMN2HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1990005531-A1 | METHOD FOR TREATING VASCULAR DISEASES | ABBOTT LABORATORIES (US) | 1990-05-31 | — | — | WO | disclosed |