Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7325933 | 0.79 | — | — | |
| Acetic Acid SCHEMBL28009360 | 0.75 | TSHR (0.47) | MAPTTSHRMEN1KMT2AAGTR1 | |
| SCHEMBL319113 | 0.73 | HSD17B10 (0.52) | MAPTTSHRMEN1KMT2ASMN1; SMN2 | |
| Ethylene SCHEMBL27749109 | 0.70 | HSD17B10 (0.48) | MAPTTSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL28040760 | 0.63 | ALDH1A1 (0.43) | MAPTMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL171809 | 0.61 | HSD17B10 (0.52) | MAPTTSHRMEN1KMT2ASMN1; SMN2 | |
| Ethoxycarbonyl Group SCHEMBL28254512 | 0.60 | HTT (0.39) | MAPTTSHRMEN1KMT2AAGTR1 | |
| SCHEMBL4444121 | 0.60 | KDM4C (0.52) | MAPTTSHRMEN1KMT2AKDM4E | |
| SCHEMBL1231890 | 0.60 | KDM4C (0.52) | MAPTTSHRMEN1KMT2AKDM4E | |
| SCHEMBL27973974 | 0.60 | ALDH1A1 (0.60) | MAPTMEN1KMT2ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1068187-A1 | PYRAZOLE INHIBITORS OF CYTOKINE PRODUCTION | ABBOTT LABORATORIES (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999051580-A1 | PYRAZOLE INHIBITORS OF CYTOKINE PRODUCTION | ABBOTT LABORATORIES (US) | 1999-10-14 | — | — | WO | disclosed |