Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 16/20 | 0.78 |
| ▸ | MMP1 | P03956 | 14/20 | 0.78 |
| ▸ | MMP9 | P14780 | 13/20 | 0.78 |
| ▸ | MMP13 | P45452 | 13/20 | 0.78 |
| ▸ | MMP14 | P50281 | 2/20 | 0.66 |
| ▸ | MMP2 | P08253 | 2/20 | 0.66 |
| ▸ | MMP7 | P09237 | 2/20 | 0.54 |
| ▸ | MMP8 | P22894 | 2/20 | 0.54 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3944045 | 0.88 | ADAM17 (1.00) | ADAM17MMP1MMP9MMP13MMP14 | |
| SCHEMBL6501738 | 0.87 | ADAM17 (0.77) | ADAM17MMP1MMP9MMP13MMP14 | |
| SCHEMBL7361693 | 0.84 | ADAM17 (0.70) | ADAM17MMP1MMP9MMP13MMP14 | |
| SCHEMBL3941442 | 0.80 | ADAM17 (1.00) | ADAM17MMP1MMP9MMP13MMP14 | |
| SCHEMBL2945763 | 0.79 | ALDH1A1 (0.69) | ALDH1A1 | |
| SCHEMBL7354960 | 0.79 | ADAM17 (0.80) | ADAM17MMP1MMP9MMP13MMP14 | |
| SCHEMBL6290001 | 0.78 | ADAM17 (0.63) | ADAM17MMP1MMP9MMP13MMP14 | |
| SCHEMBL6502198 | 0.78 | ADAM17 (0.70) | ADAM17MMP1MMP9MMP13MMP14 | |
| SCHEMBL3948476 | 0.77 | ADAM17 (0.69) | ADAM17MMP1MMP9MMP13MMP14 | |
| SCHEMBL6887919 | 0.77 | ADAM17 (0.59) | ADAM17MMP1MMP9MMP13MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6326516-B1 | RHEUMATIC DISEASES; SEPSIS; ANTIULCER AGENTS | AMERICAN CYANAMID COMPANY | 2001-12-04 | — | — | US | disclosed |
| EP-1147078-A1 | ACETYLENIC (BETA)-SULFONAMIDO AND PHOSPHINIC ACID AMIDE HYDROXAMIC ACID TACE INHIBITORS | American Cyanamid Company (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000044711-A1 | ACETYLENIC $G(b)-SULFONAMIDO AND PHOSPHINIC ACID AMIDE HYDROXAMIC ACID TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | disclosed |