Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 20/20 | 0.44 |
| ▸ | PDE4A | P27815 | 16/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 16/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 16/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7354542 | 0.91 | PDE4D (0.44) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7357012 | 0.88 | PDE4D (0.44) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7363109 | 0.85 | PDE4D (0.42) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7353023 | 0.82 | PDE4D (0.48) | PDE4DPDE4APDE4BPDE4CABCB11 | |
| SCHEMBL7357173 | 0.82 | PDE4B (0.62) | PDE4DPDE4APDE4BPDE4CABCB11 | |
| SCHEMBL7358219 | 0.78 | SLC6A3 (0.35) | — | |
| SCHEMBL6822446 | 0.78 | PDE4D (0.67) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL6814857 | 0.75 | PDE4D (0.54) | PDE4DPDE4APDE4BPDE4CABCB11 | |
| SCHEMBL7358250 | 0.75 | PDE4D (0.73) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL8553907 | 0.75 | CA12 (0.52) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | disclosed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | disclosed |