Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.38 |
| ▸ | HMGCR | P04035 | 1/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.33 |
| ▸ | PRKCA | P17252 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10817851 | 0.74 | ALDH1A1 (0.33) | ALOX5PTGS2HMGCRPLA2G2APRKCA | |
| SCHEMBL10817847 | 0.74 | ALDH1A1 (0.33) | ALOX5PTGS2HMGCRPLA2G2APRKCA | |
| SCHEMBL364135 | 0.74 | — | — | |
| SCHEMBL9812598 | 0.74 | — | — | |
| SCHEMBL9838225 | 0.72 | ALOX5 (0.37) | ALOX5PTGS2HMGCRPLA2G2APRKCA | |
| SCHEMBL24381615 | 0.71 | APEX1 (0.34) | ALOX5PTGS2HMGCR | |
| SCHEMBL364738 | 0.71 | ALOX5 (0.41) | ALOX5PTGS2HMGCRPLA2G2APRKCA | |
| SCHEMBL9767231 | 0.69 | — | — | |
| SCHEMBL2279671 | 0.69 | PTGS2 (0.35) | ALOX5PTGS2HMGCRPLA2G2APRKCA | |
| SCHEMBL1665531 | 0.69 | ALOX5 (0.33) | ALOX5PTGS2HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579769-B1 | 2- AND 5-ALKYL AND PHENYL SUBSTITUTED 4-(1-HYDROXY, 1-ACYLOXY OR 1-CARBAMOYLOXY)-5-HYDROXY-2(5H)-FURANONES AS ANTI-INFLAMMATORY AGENTS | ALLERGAN INC (US) | 1998-10-21 | — | — | EP | disclosed |
| EP-0525002-B1 | 2[5H]-FURANONES SUBSTITUTED IN THE 3 POSITION, AS Ca 2+ CHANNEL ANTAGONISTS AND ANTI-INFLAMMATORY AGENTS | ALLERGAN INC (US) | 1998-05-13 | — | — | EP | disclosed |
| EP-0841332-A1 | Method for preparing alpha-methylene-beta-methyl-gamma-butyrolactone and 4-hydroxy-butyric aldehyde as well as 2-hydroxa-3-methylene-4-methyltetrahydrofuran being valuable intermediates | Degussa Aktiengesellschaft (DE) | 1998-05-13 | — | — | EP | disclosed |
| EP-0755389-A1 | 3 AND 5 ALKYL AND PHENYL 4-(HYDROXY OR ACYLOXY)-ALKYL SUBSTITUTED 2(5H)-FURANONES AS ANTI-INFLAMMATORY AGENTS | Allergan (US) | 1997-01-29 | — | — | EP | disclosed |
| WO-1995028394-A1 | 3 AND 5 ALKYL AND PHENYL 4-(HYDROXY OR ACYLOXY)-ALKYL SUBSTITUTED 2(5H)-FURANONES AS ANTI-INFLAMMATORY AGENTS | ALLERGAN (US) | 1995-10-26 | — | — | WO | disclosed |
| US-5451686-A | 3 and 5 alkyl and phenyl 4-(hydroxy or acyloxy)-alkyl substituted 2(5H)-furanones as anti-inflammatory agents | ALLERGAN, INC. (US) | 1995-09-19 | — | — | US | disclosed |
| US-5376676-A | Process of using anti-inflammatory furanones as selective calcium channel inhibitors | ALLERGAN, INC. (US) | 1994-12-27 | — | — | US | disclosed |
| US-5322953-A | Antiinflammatory agents; intermediates for 2-furanone compounds | ALLERGAN, INC. (US) | 1994-06-21 | — | — | US | disclosed |
| US-5298633-A | Silane intermediates | ALLERGAN, INC. (US) | 1994-03-29 | — | — | US | disclosed |
| EP-0579769-A1 | 2- AND 5-ALKYL AND PHENYL SUBSTITUTED 4-(1-HYDROXY, 1-ACYLOXY OR 1-CARBAMOYLOXY)-5-HYDROXY-2(5H)-FURANONES AS ANTI-INFLAMMATORY AGENTS | ALLERGAN, INC. (US) | 1994-01-26 | — | — | EP | disclosed |
| WO-1992019609-A1 | SUBSTITUTED DIHYDROXY-BIS-[5-HYDROXY-2(5H)-FURANONE-4-YL]-ALKANES AS ANTI-INFLAMMATORY AGENTS | ALLERGAN, INC. (US) | 1992-11-12 | — | — | WO | disclosed |
| WO-1992019610-A1 | 2- AND 5-ALKYL AND PHENYL SUBSTITUTED 4-(1-HYDROXY, 1-ACYLOXY OR 1-CARBAMOYLOXY)-5-HYDROXY-2(5H)-FURANONES AS ANTI-INFLAMMATORY AGENTS | ALLERGAN, INC. (US) | 1992-11-12 | — | — | WO | disclosed |
| US-5082954-A | Intermediates and processes for preparing 4-substituted 2-5(H)-furanones as anti-inflammatory agents | ALLERGAN, INC. (US) | 1992-01-21 | — | — | US | disclosed |
| WO-1991016048-A1 | 2(5H)-FURANONES SUBSTITUTED IN THE 3 POSITION, AS Ca2+ CHANNEL ANTAGONISTS AND ANTI-INFLAMMATORY AGENTS | ALLERGAN, INC. (US) | 1991-10-31 | — | — | WO | disclosed |
| WO-1991016047-A1 | 4-(OXYGEN, SULFUR OR NITROGEN SUBSTITUTED)-METHYL 5-HYDROXY-2(5H)-FURANONES AS ANTI-INFLAMMATORY AGENTS | ALLERGAN, INC. (US) | 1991-10-31 | — | — | WO | disclosed |
| WO-1991016055-A1 | 2(5H)-FURANONES SUBSTITUTED IN THE 5 AND OR IN THE 4 POSITION, AS ANTI-INFLAMMATORY AGENTS | ALLERGAN, INC. (US) | 1991-10-31 | — | — | WO | disclosed |
| US-5045564-A | Calcium channel antagonists | ALLERGAN, INC. (US) | 1991-09-03 | — | — | US | disclosed |
| US-5043457-A | 2(5H)-furanones substituted in the 3 position, as Ca2+ channel antagonists and anti-inflammatory agents | ALLERGAN, INC. (US) | 1991-08-27 | — | — | US | disclosed |
| US-5037811-A | Antiboby inhibitors; antigrowth agents/biological/; antiarthritic agents | ALLERGAN, INC. (US) | 1991-08-06 | — | — | US | disclosed |
| EP-0372940-A2 | Anti-inflammatory 2-furanones | ALLERGAN, INC (US) | 1990-06-13 | — | — | EP | disclosed |