Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11372873 | 0.77 | FGFR1 (0.35) | FGFR1FGFR2KDM4EALDH1A1HPGD | |
| SCHEMBL27567602 | 0.75 | BRD4 (0.38) | FGFR1FGFR2KDM4EALDH1A1HPGD | |
| SCHEMBL6232025 | 0.73 | MAPK1 (0.40) | KDM4EALDH1A1HPGDHSD17B10TLR7 | |
| SCHEMBL6233928 | 0.73 | TUBB4A (0.40) | TLR7PKMGAAMAPTLMNA | |
| SCHEMBL6232876 | 0.72 | CYP1A2 (0.42) | FGFR1FGFR2KDM4EALDH1A1HPGD | |
| SCHEMBL6237667 | 0.72 | CYP1A2 (0.41) | FGFR1FGFR2KDM4EALDH1A1HPGD | |
| SCHEMBL55693 | 0.72 | ALDH1A1 (0.44) | FGFR1FGFR2KDM4EALDH1A1HPGD | |
| SCHEMBL31024286 | 0.71 | BRD4 (0.38) | KDM4EALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL24113223 | 0.70 | NR4A2 (0.48) | KDM4EALDH1A1HPGDKMT2AHSD17B10 | |
| SCHEMBL11371143 | 0.69 | RHEB (0.38) | FGFR1FGFR2KDM4EHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086076-A1 | SULFONAMIDE INHIBITORS OF ASPARTYL PROTEASE | Vertex Pharmaceuticals Incorporated (US) | 2001-03-28 | — | — | EP | disclosed |
| WO-1999065870-A2 | SULFONAMIDE INHIBITORS OF ASPARTYL PROTEASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1999-12-23 | — | — | WO | disclosed |
| US-5023337-A | Chemical process for the preparation of pharmaceutically active compounds | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) | 1991-06-11 | — | — | US | disclosed |