Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 16/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | PGK1 | P00558 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7016783 | 0.89 | F2 (0.49) | F2PRSS1MAOBPGK1KDM4E | |
| SCHEMBL7159962 | 0.78 | F2 (0.70) | F2PRSS1 | |
| SCHEMBL7365127 | 0.73 | PGK1 (0.41) | F2MAOBPGK1KDM4EALDH1A1 | |
| SCHEMBL7364554 | 0.71 | F2 (0.57) | F2PRSS1 | |
| SCHEMBL3261238 | 0.70 | F7 (0.49) | F2KDM4EALDH1A1 | |
| SCHEMBL3242830 | 0.69 | F2 (0.66) | F2PRSS1 | |
| SCHEMBL7015258 | 0.69 | F2 (0.44) | F2PRSS1PGK1KDM4EALDH1A1 | |
| SCHEMBL7158554 | 0.69 | F2 (0.63) | F2PRSS1 | |
| SCHEMBL5481633 | 0.68 | F2 (0.52) | F2PRSS1MAOB | |
| SCHEMBL5477413 | 0.67 | F2 (0.53) | F2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1259506-A1 | PYRAZINONE THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2002-11-27 | — | — | EP | disclosed |
| WO-2001038323-A1 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2001-05-31 | — | — | WO | disclosed |