Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 19/20 | 0.57 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7158554 | 0.90 | F2 (0.63) | F2PRSS1 | |
| SCHEMBL5477413 | 0.82 | F2 (0.53) | F2PRSS1 | |
| SCHEMBL7715115 | 0.82 | F2 (0.65) | F2 | |
| SCHEMBL5475081 | 0.81 | KDM4E (0.47) | F2PRSS1 | |
| SCHEMBL5481633 | 0.80 | F2 (0.52) | F2PRSS1 | |
| SCHEMBL5855071 | 0.80 | F2 (0.68) | F2PRSS1 | |
| SCHEMBL23460612 | 0.79 | LMNA (0.41) | F2PRSS1MEN1KMT2A | |
| SCHEMBL8292334 | 0.78 | F2 (0.49) | F2PRSS1 | |
| SCHEMBL23460733 | 0.78 | F2 (0.39) | F2PRSS1MEN1KMT2A | |
| SCHEMBL7159962 | 0.77 | F2 (0.70) | F2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1259506-A1 | PYRAZINONE THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2002-11-27 | — | — | EP | disclosed |
| US-6387911-B1 | Pyrazinone thrombin inhibitors | MERCK & CO., INC. | 2002-05-14 | — | — | US | disclosed |
| WO-2001038323-A1 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2001-05-31 | — | — | WO | disclosed |