Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.43 |
| ▸ | KCNJ1 | P48048 | 4/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7363839 | 0.81 | CYP1A2 (0.33) | CASP3SENP8SENP7SENP6 | |
| SCHEMBL18913824 | 0.73 | TSHR (0.69) | KCNH2KCNJ1LOXL2TSHRSIGMAR1 | |
| Methylamine SCHEMBL27524577 | 0.73 | SIGMAR1 (0.61) | KCNH2KCNJ1LOXL2TSHRSIGMAR1 | |
| SCHEMBL6089703 | 0.71 | CYP3A4 (0.42) | KCNH2TSHRMAPTALDH1A1 | |
| SCHEMBL9640859 | 0.71 | KCNH2 (0.68) | KCNH2KCNJ1LOXL2TSHRVCAM1 | |
| Dinitrophenylene SCHEMBL27864502 | 0.70 | TSHR (0.57) | CASP3SENP8SENP7SENP6TSHR | |
| SCHEMBL30758863 | 0.70 | TSHR (0.69) | KCNH2KCNJ1LOXL2TSHRSIGMAR1 | |
| SCHEMBL9055361 | 0.70 | TSHR (0.55) | KCNH2KCNJ1LOXL2TSHRSIGMAR1 | |
| SCHEMBL6481704 | 0.69 | ALDH1A1 (0.69) | KCNH2KCNJ1LOXL2TSHRSIGMAR1 | |
| SCHEMBL1163856 | 0.69 | SIGMAR1 (0.65) | KCNH2KCNJ1LOXL2TSHRSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892780-A1 | M-AMIDINO PHENYL ANALOGS AS FACTOR Xa INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997030971-A1 | M-AMIDINO PHENYL ANALOGS AS FACTOR Xa INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-08-28 | — | — | WO | disclosed |