Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7366299 | 0.93 | PLAU (0.38) | PLAUMAPTSMN1; SMN2LMNANPSR1 | |
| SCHEMBL7448814 | 0.90 | SMN1; SMN2 (0.36) | PLAUMAPTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL7371684 | 0.89 | ALDH1A1 (0.37) | MAPTSMN1; SMN2LMNAALDH1A1POLB | |
| SCHEMBL7049646 | 0.88 | PLAU (0.43) | PLAUMAPTSMN1; SMN2LMNAPDE4A | |
| SCHEMBL7378754 | 0.88 | PLAU (0.41) | PLAUMAPTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL7377977 | 0.81 | PLAU (0.36) | PLAUMAPTSMN1; SMN2PDE4APDE4B | |
| SCHEMBL7371411 | 0.81 | MAPT (0.39) | PLAUMAPTSMN1; SMN2LMNA | |
| SCHEMBL7378343 | 0.81 | PDE4A (0.41) | PLAUPDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL7379597 | 0.80 | PLAU (0.47) | PLAUPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7369185 | 0.80 | PLAU (0.36) | PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |
| EP-1077945-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-2000005214-A2 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2000-02-03 | — | — | WO | disclosed |