Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7363430 | 0.88 | PLAU (0.42) | PLAUALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL7048344 | 0.87 | PLAU (0.42) | PLAUNR1I2ALDH1A1MAPTLMNA | |
| SCHEMBL7448814 | 0.84 | SMN1; SMN2 (0.36) | PLAUALDH1A1MAPTLMNAHTT | |
| SCHEMBL7366299 | 0.83 | PLAU (0.38) | PLAUMAPTLMNASMN1; SMN2NPSR1 | |
| SCHEMBL7371684 | 0.82 | ALDH1A1 (0.37) | ALDH1A1MAPTLMNASMN1; SMN2MEN1 | |
| SCHEMBL7369185 | 0.81 | PLAU (0.36) | PLAU | |
| SCHEMBL7374054 | 0.80 | PLAU (0.38) | PLAUALDH1A1 | |
| SCHEMBL7368832 | 0.77 | F2 (0.40) | ALDH1A1MAPT | |
| SCHEMBL6437292 | 0.76 | PLAU (0.53) | PLAUL3MBTL1NR1I2ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL7366875 | 0.76 | PLAU (0.42) | PLAUALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077945-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-2000005214-A2 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2000-02-03 | — | — | WO | disclosed |