Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | DAGLA | Q9Y4D2 | 2/20 | 0.34 |
| ▸ | CXCR3 | P49682 | 4/20 | 0.33 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 2/20 | 0.32 |
| ▸ | MMP2 | P08253 | 2/20 | 0.32 |
| ▸ | MMP9 | P14780 | 2/20 | 0.32 |
| ▸ | MMP8 | P22894 | 2/20 | 0.32 |
| ▸ | MMP13 | P45452 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7363430 | 0.93 | PLAU (0.42) | PLAUMAPTSMN1; SMN2LMNANPSR1 | |
| SCHEMBL7371411 | 0.88 | MAPT (0.39) | PLAUTAS2R14MAPTSMN1; SMN2LMNA | |
| SCHEMBL7448814 | 0.86 | SMN1; SMN2 (0.36) | PLAUTAS2R14MAPTSMN1; SMN2LMNA | |
| SCHEMBL7371684 | 0.85 | ALDH1A1 (0.37) | TAS2R14MAPTSMN1; SMN2LMNA | |
| SCHEMBL7378754 | 0.83 | PLAU (0.41) | PLAUMAPTSMN1; SMN2LMNANPSR1 | |
| SCHEMBL7049646 | 0.81 | PLAU (0.43) | PLAUMAPTSMN1; SMN2LMNAMMP1 | |
| SCHEMBL7371892 | 0.81 | TAS2R14 (0.40) | PLAUTAS2R14MAPTSMN1; SMN2LMNA | |
| SCHEMBL7378343 | 0.79 | PDE4A (0.41) | PLAUCXCR3MMP1MMP2MMP9 | |
| SCHEMBL6434442 | 0.79 | PLAU (0.49) | PLAUTAS2R14MAPTSMN1; SMN2LMNA | |
| SCHEMBL7379322 | 0.79 | DAGLA (0.45) | PLAUTAS2R14MAPTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |
| EP-1077945-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-2000005214-A2 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2000-02-03 | — | — | WO | disclosed |