Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.38 |
| ▸ | CCR6 | P51684 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9148490 | 0.88 | NPC1 (0.53) | ALDH1A1MAPTHPGDHTTSMN1; SMN2 | |
| SCHEMBL181586 | 0.81 | ALDH1A1 (0.50) | ALDH1A1MAPTHPGDHTTSMN1; SMN2 | |
| SCHEMBL29922833 | 0.81 | ALDH1A1 (0.50) | ALDH1A1MAPTHPGDHTTSMN1; SMN2 | |
| SCHEMBL30598769 | 0.81 | L3MBTL1 (0.51) | ALDH1A1MAPTHPGDHTTSMN1; SMN2 | |
| SCHEMBL7363630 | 0.80 | ALDH1A1 (0.70) | ALDH1A1MAPTHPGDHTTSMN1; SMN2 | |
| SCHEMBL30485561 | 0.79 | ALDH1A1 (0.46) | ALDH1A1MAPTHPGDHTTSMN1; SMN2 | |
| SCHEMBL7360395 | 0.79 | ALDH1A1 (0.46) | ALDH1A1MAPTHPGDHTTSMN1; SMN2 | |
| SCHEMBL7494720 | 0.79 | ALDH1A1 (0.44) | ALDH1A1MAPTHPGDHTTSMN1; SMN2 | |
| SCHEMBL26091873 | 0.77 | ALDH1A1 (0.44) | ALDH1A1MAPTHPGDHTTSMN1; SMN2 | |
| SCHEMBL29923063 | 0.77 | ALDH1A1 (0.58) | ALDH1A1MAPTHPGDHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5385922-A | Cardiovascular and gastrointestinal disorders; antiischemic and cardiotonic agents | CEDONA PHARMACEUTICALS B.V. (NL) | 1995-01-31 | — | — | US | disclosed |
| US-5378718-A | Cardiovascular activity, hypotensive | CEDONA PHARMACEUTICALS B.V. (NL) | 1995-01-03 | — | — | US | disclosed |
| EP-0547104-A1 | THIAZOLIDIN DERIVATIVES | CEDONA PHARMACEUTICALS B.V. (NL) | 1993-06-23 | — | — | EP | disclosed |
| EP-0541634-A1 | 1,4-DIHYDROPYRIDINE DERIVATIVES | CEDONA PHARMACEUTICALS B.V. (NL) | 1993-05-19 | — | — | EP | disclosed |
| WO-1992004337-A1 | THIAZOLIDIN DERIVATIVES | CEDONA PHARMACEUTICALS BV (NL) | 1992-03-19 | — | — | WO | disclosed |
| WO-1992002503-A1 | NOVEL 1,4-DIHYDROPYRIDINE DERIVATIVES | CEDONA PHARMACEUTICALS BV (NL) | 1992-02-20 | — | — | WO | disclosed |