Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LPO | P22079 | 2/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.34 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3362031 | 0.80 | NAAA (0.46) | GRM5MAPTNAAA | |
| SCHEMBL7831399 | 0.73 | NAAA (0.44) | MAPTNOTUMNAAAKDM4EALDH1A1 | |
| SCHEMBL9223438 | 0.73 | LPO (0.39) | MAPTLPOKDM4EALDH1A1HSD17B10 | |
| SCHEMBL6929124 | 0.67 | KDM4E (0.44) | MAPTLPOKDM4EALDH1A1HPGD | |
| SCHEMBL13681612 | 0.66 | NOTUM (0.42) | GRM5MAPTNOTUMNAAAKDM4E | |
| SCHEMBL11357164 | 0.66 | KMT2A (0.40) | MAPTLPOKDM4EALDH1A1HSD17B10 | |
| SCHEMBL16335477 | 0.66 | NAAA (0.54) | MAPTNOTUMNAAAALDH1A1HPGD | |
| SCHEMBL10374140 | 0.65 | MAPT (0.50) | MAPTLPONOTUMKDM4EALDH1A1 | |
| SCHEMBL18117001 | 0.65 | NOTUM (0.31) | NOTUM | |
| SCHEMBL13681626 | 0.65 | MAPT (0.46) | GRM5MAPTNOTUMKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0415981-A4 | RETROVIRAL PROTEASE INHIBITORS | — | 1991-10-09 | — | — | EP | disclosed |
| EP-0415981-A1 | RETROVIRAL PROTEASE INHIBITORS | ABBOTT LABORATORIES (US) | 1991-03-13 | — | — | EP | disclosed |
| WO-1989010752-A1 | RETROVIRAL PROTEASE INHIBITORS | ABBOTT LABORATORIES (US) | 1989-11-16 | — | — | WO | disclosed |