Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 4/20 | 0.41 |
| ▸ | MMP13 | P45452 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 2/20 | 0.40 |
| ▸ | ROS1 | P08922 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 3/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
| ▸ | MMP7 | P09237 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP10 | P09238 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7355321 | 0.90 | MMP1 (0.40) | ADAM17MMP13MMP1ROS1RPS6KB1 | |
| SCHEMBL7354778 | 0.85 | ADAM17 (0.45) | ADAM17MMP13MMP1HDAC6MMP3 | |
| SCHEMBL7362515 | 0.82 | ADAM17 (0.47) | ADAM17MMP13MMP1MMP3ADAMTS4 | |
| SCHEMBL7363680 | 0.78 | ADAM17 (0.55) | ADAM17MMP13MMP1MMP3MMP2 | |
| SCHEMBL7356674 | 0.75 | ADAM17 (0.44) | ADAM17MMP13MMP1HDAC6MMP3 | |
| SCHEMBL6796783 | 0.72 | MMP1 (0.43) | ADAM17MMP13MMP1MMP3MMP8 | |
| SCHEMBL7353437 | 0.72 | ADAM17 (0.46) | ADAM17MMP13MMP1MMP3ADAMTS4 | |
| SCHEMBL7355311 | 0.69 | MMP13 (0.54) | ADAM17MMP13MMP1MMP3MMP7 | |
| SCHEMBL7427244 | 0.68 | ADAM17 (0.42) | ADAM17MMP13MMP1ADAMTS4TRPV1 | |
| SCHEMBL7424285 | 0.67 | ADAM17 (0.43) | ADAM17MMP13MMP1ADAMTS4MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077974-A1 | SUBSTITUTED ARYL HYDROXAMIC ACIDS AS METALLOPROTEINASE INHIBITORS | Du Pont Pharmaceuticals Company (US) | 2001-02-28 | — | — | EP | claimed |
| WO-1999058528-A1 | SUBSTITUTED ARYL HYDROXAMIC ACIDS AS METALLOPROTEINASE INHIBITORS | BRISTOL-MYERS SQUIBB PHARMA COMPANY. (US) | 1999-11-18 | — | — | WO | claimed |