Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 7/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | STAT1 | P42224 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559726 | 0.78 | ESR1 (0.46) | EPHX2EPHX1NPC1RAB9APOLB | |
| SCHEMBL10243175 | 0.76 | MAPT (0.50) | NAMPTEPHX2MAPTNPC1STAT1 | |
| SCHEMBL9409512 | 0.73 | FFAR1 (0.42) | NAMPTEPHX2EPHX1MAPTNPC1 | |
| SCHEMBL20705482 | 0.73 | RAB9A (0.50) | NAMPTMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2452371 | 0.70 | KDM1A (0.48) | NAMPTEPHX2EPHX1TLR8TLR7 | |
| SCHEMBL8414100 | 0.70 | P2RY14 (0.47) | NAMPTEPHX2EPHX1TLR8TLR7 | |
| SCHEMBL7391329 | 0.70 | FDFT1 (0.44) | MAPTDGAT1 | |
| SCHEMBL571141 | 0.70 | KDM1A (0.60) | MAPTNPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL2414763 | 0.70 | P2RY14 (0.44) | NAMPTEPHX2EPHX1MAPTNPC1 | |
| SCHEMBL15254117 | 0.69 | P2RY14 (0.56) | NAMPTNPC1RAB9ATLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5880284-A | HAVING ANTITHROMBOTIC, ANTIAGGREGATORY AND TUMOR- OR METASTASES-INHIBITING EFFECTS | DR. KARL THOMAE GMBH (DE) | 1999-03-09 | — | — | US | disclosed |
| US-5681841-A | PREVENTION CELL AGGREGATION | KARL THOMAE GMBH (DE) | 1997-10-28 | — | — | US | disclosed |
| WO-1995024405-A1 | IMIDAZOLIDIN-2-ONES, MEDICAMENTS CONTAINING THESE COMPOUNDS AND METHOD OF PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1995-09-14 | — | — | WO | disclosed |
| EP-0587134-A2 | Cyclic urea derivatives, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1994-03-16 | — | — | EP | disclosed |