Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.60 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.55 |
| ▸ | RBP4 | P02753 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15254117 | 0.86 | P2RY14 (0.56) | KDM1ARIPK1RBP4KCNH2NPC1 | |
| SCHEMBL2452371 | 0.84 | KDM1A (0.48) | KDM1ARIPK1RBP4KCNH2P2RY14 | |
| SCHEMBL5694984 | 0.84 | KDM1A (0.45) | KDM1ARIPK1RBP4KCNH2HRH3 | |
| SCHEMBL20705482 | 0.84 | RAB9A (0.50) | KDM1ANPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL8414100 | 0.84 | P2RY14 (0.47) | KDM1ARIPK1RBP4KCNH2HRH3 | |
| SCHEMBL13328860 | 0.83 | RIPK1 (0.58) | RIPK1KCNH2HRH3NPC1RAB9A | |
| SCHEMBL571076 | 0.81 | P2RY14 (0.45) | KDM1ARIPK1RBP4NPC1RAB9A | |
| SCHEMBL571736 | 0.81 | P2RY14 (0.47) | KDM1ARIPK1RBP4KCNH2NPC1 | |
| SCHEMBL20124850 | 0.81 | P2RY14 (0.45) | KDM1ARIPK1RBP4KCNH2HSD11B1 | |
| SCHEMBL6126281 | 0.81 | P2RY14 (0.45) | KDM1ARIPK1RBP4P2RY14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 89 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10196373-B2 | Substituted 2-hydroxy-4-(2-(phenylsulfonamido)acetamido)benzoic acid analogs as inhibitors of STAT protein | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2019-02-05 | — | — | US | disclosed |
| EP-3008045-B1 | ANTIBACTERIAL THIAZOLECARBOXYLIC ACIDS | ANTABIO SAS (FR) | 2018-05-09 | — | — | EP | disclosed |
| US-9914712-B2 | Antibacterial thiazolecarboxylic acids | ANTABIO SAS (FR) | 2018-03-13 | — | — | US | disclosed |
| US-9914712-B2 | Antibacterial thiazolecarboxylic acids | ANTABIO SAS (FR) | 2018-03-13 | — | — | US | disclosed |
| US-20160272601-A1 | Antibacterial Thiazolecarboxylic Acids | ANTABIO SAS (FR) | 2016-09-22 | — | — | US | disclosed |
| US-20160272601-A1 | Antibacterial Thiazolecarboxylic Acids | ANTABIO SAS (FR) | 2016-09-22 | — | — | US | disclosed |
| EP-2831077-B1 | BICYCLIC PYRAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-04-27 | — | — | EP | disclosed |
| EP-2831077-B1 | BICYCLIC PYRAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-04-27 | — | — | EP | disclosed |
| US-9120805-B2 | Substituted pyrrolo[1,2-A]pyrazin-1-ones and pyrazolo[1,5-A]pyrazin-4-ones as inhibitors of tankyrase and poly(ADP-ribose)polymerase activity | MERCK PATENT GMBH (DE) | 2015-09-01 | — | — | US | disclosed |
| US-9120805-B2 | Substituted pyrrolo[1,2-A]pyrazin-1-ones and pyrazolo[1,5-A]pyrazin-4-ones as inhibitors of tankyrase and poly(ADP-ribose)polymerase activity | MERCK PATENT GMBH (DE) | 2015-09-01 | — | — | US | disclosed |
| US-5681841-A | PREVENTION CELL AGGREGATION | KARL THOMAE GMBH (DE) | 1997-10-28 | — | — | US | disclosed |
| WO-1996002514-A1 | UREA AND CARBAMIC ACID DERIVATIVES, DRUGS CONTAINING THESE COMPOUNDS, AND PROCESS FOR THEIR PREPARATION | DR. KARL THOMAE GMBH (DE) | 1996-02-01 | — | — | WO | disclosed |
| WO-1995024405-A1 | IMIDAZOLIDIN-2-ONES, MEDICAMENTS CONTAINING THESE COMPOUNDS AND METHOD OF PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1995-09-14 | — | — | WO | disclosed |
| EP-0648130-A1 | RADIOIODINATED BENZOVESAMICOL ANALOGS FOR CHOLINERGIC NERVE MAPPING | THE UNIVERSITY OF MICHIGAN (US) | 1995-04-19 | — | — | EP | disclosed |
| CN-1094035-A | Carboxylic acid derivative contains pharmaceutical composition of these compounds and preparation method thereof | THOMAE GMBH DR K (DE) | 1994-10-26 | — | — | CN | disclosed |
| EP-0604800-A1 | 4- 4- 4-(carboxyalkyl)-phenyl amino carbonyl -phenyl -piperedines as aggregation inhibitors | Dr. Karl Thomae GmbH (DE) | 1994-07-06 | — | — | EP | disclosed |
| EP-0587134-A2 | Cyclic urea derivatives, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1994-03-16 | — | — | EP | disclosed |
| EP-0648130-A4 | RADIOIODINATED BENZOVESAMICOL ANALOGS FOR CHOLINERGIC NERVE MAPPING. | UNIV MICHIGAN (US) | 1994-01-26 | — | — | EP | disclosed |
| US-5077035-A | Scintigraphic imaging of brain; Alzheimer*s diagnosis | THE UNIVERSITY OF MICHIGAN (US) | 1991-12-31 | — | — | US | disclosed |
| WO-1991017776-A1 | RADIOIODINATED BENZOVESAMICOL ANALOGS FOR CHOLINERGIC NERVE MAPPING | THE UNIVERSITY OF MICHIGAN (US) | 1991-11-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160272601-A1 | Antibacterial Thiazolecarboxylic Acids | ME1, TALDO1, COASY | KDM1A 1249/4885RIPK1 3734/4885RBP4 2964/4885 |
| US-10196373-B2 | Substituted 2-hydroxy-4-(2-(phenylsulfonamido)acetamido)benzoic acid analogs as inhibitors of STAT protein | STAT3, STAT1, STAT4 | KDM1A 2433/4885RIPK1 1300/4885RBP4 3135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.