Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 5/20 | 0.42 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | BTK | Q06187 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364163 | 1.00 | JAK3 (0.48) | JAK3JAK2SIRT2SIRT1SIRT3 | |
| SCHEMBL7367589 | 0.85 | MMP1 (0.45) | EGFRLTB4RHDAC4MMP1MMP2 | |
| SCHEMBL7367827 | 0.84 | EGFR (0.49) | JAK3JAK2SIRT2SIRT1SIRT3 | |
| SCHEMBL7367833 | 0.84 | EGFR (0.49) | JAK3JAK2SIRT2SIRT1SIRT3 | |
| SCHEMBL7486921 | 0.83 | LTB4R (0.41) | EGFRNPC1RAB9ALTB4RKDR | |
| SCHEMBL7486915 | 0.83 | LTB4R (0.41) | EGFRNPC1RAB9ALTB4RKDR | |
| SCHEMBL7362038 | 0.80 | HDAC1 (0.46) | SIRT2SIRT1SIRT3EGFRMEN1 | |
| SCHEMBL7362037 | 0.80 | HDAC1 (0.46) | SIRT2SIRT1SIRT3EGFRMEN1 | |
| SCHEMBL6800292 | 0.79 | ABCG2 (0.55) | JAK3EGFRMEN1NPC1RAB9A | |
| SCHEMBL6795594 | 0.77 | CA12 (0.49) | SIRT2SIRT1EGFRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874845-B1 | PYRIDO (2,3-B) PYRAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-03-06 | — | — | EP | disclosed |
| US-6117875-A | Pyrido (2,3-B) pyrazine derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-09-12 | — | — | US | disclosed |
| EP-0874845-A1 | PYRIDO (2,3-B) PYRAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997024355-A1 | PYRIDO (2,3-B) PYRAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-10 | — | — | WO | disclosed |