Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.40 |
| ▸ | HTR2C | P28335 | 4/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.34 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | PTPRC | P08575 | 1/20 | 0.33 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.33 |
| ▸ | PTPN9 | P43378 | 1/20 | 0.33 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7366843 | 0.87 | GRM5 (0.40) | AKR1B1TRPV3HTR6PTGDR2ALDH1A1 | |
| SCHEMBL7449426 | 0.82 | HTR6 (0.40) | HTR6PTGDR2MEN1MAPTKMT2A | |
| SCHEMBL7368039 | 0.82 | GRM5 (0.41) | HTR2AKCNH2AKR1B1HTR6MEN1 | |
| SCHEMBL7366907 | 0.81 | CA12 (0.51) | — | |
| SCHEMBL6134300 | 0.77 | GRM5 (0.47) | AKR1B1HTR6 | |
| SCHEMBL7366863 | 0.76 | HTR6 (0.46) | KCNH2AKR1B1HTR6PTGDR2MEN1 | |
| SCHEMBL7446863 | 0.74 | HAO1 (0.40) | KCNH2HTR6MEN1LMNAMAPT | |
| SCHEMBL7439517 | 0.73 | HAO1 (0.40) | HTTPKMHAO1 | |
| SCHEMBL7367382 | 0.71 | CA12 (0.43) | KCNH2AKR1B1HTTSMN1; SMN2 | |
| SCHEMBL7372249 | 0.71 | GRM5 (0.46) | KCNH2AKR1B1MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244669-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001040230-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-06-07 | — | — | WO | disclosed |