Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6134300 | 0.86 | GRM5 (0.47) | GRM5CA12CA1CA2CA9 | |
| SCHEMBL7366907 | 0.85 | CA12 (0.51) | GRM5CA12CA1CA2CA9 | |
| SCHEMBL7370542 | 0.81 | CA12 (0.54) | GRM5CA12CA1CA2CA9 | |
| SCHEMBL7368039 | 0.77 | GRM5 (0.41) | GRM5CA12CA1CA2CA9 | |
| SCHEMBL7367382 | 0.77 | CA12 (0.43) | GRM5CA12CA1CA2CA9 | |
| SCHEMBL7366843 | 0.72 | GRM5 (0.40) | GRM5CA12CA1CA2AKR1B1 | |
| SCHEMBL7366863 | 0.72 | HTR6 (0.46) | GRM5AKR1B1KCNH2MEN1KMT2A | |
| SCHEMBL7439517 | 0.72 | HAO1 (0.40) | GRM5CA12CA1CA2CA9 | |
| SCHEMBL10354233 | 0.72 | HTR6 (0.62) | CA12CA1CA2CA9AKR1B1 | |
| SCHEMBL7364220 | 0.71 | HTR2A (0.40) | AKR1B1KCNH2HAO1MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244669-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001040230-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-06-07 | — | — | WO | disclosed |