Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364220 | 0.87 | HTR2A (0.40) | AKR1B1HTR6PTGDR2TRPV3LMNA | |
| SCHEMBL6134300 | 0.81 | GRM5 (0.47) | GRM5AKR1B1HTR6AGTR1CA12 | |
| SCHEMBL7368039 | 0.81 | GRM5 (0.41) | GRM5AKR1B1HTR6CA12CA1 | |
| SCHEMBL7366863 | 0.80 | HTR6 (0.46) | GRM5AKR1B1HTR6PTGDR2TP53 | |
| SCHEMBL7366907 | 0.77 | CA12 (0.51) | GRM5CA12CA1CA2 | |
| SCHEMBL7449426 | 0.77 | HTR6 (0.40) | GRM5HTR6PTGDR2TP53GAA | |
| SCHEMBL5671824 | 0.77 | AGTR1 (0.45) | GRM5AKR1B1HTR6AGTR1CA12 | |
| SCHEMBL7446863 | 0.75 | HAO1 (0.40) | GRM5HTR6CA12CA1CA2 | |
| SCHEMBL7367382 | 0.75 | CA12 (0.43) | GRM5AKR1B1CA12CA1CA2 | |
| SCHEMBL10354233 | 0.74 | HTR6 (0.62) | AKR1B1HTR6AGTR1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244669-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001040230-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-06-07 | — | — | WO | disclosed |