Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367342 | 0.76 | GRM2 (0.51) | CYP2C19HSD11B1APEX1SLC1A3SLC1A2 | |
| SCHEMBL8326400 | 0.74 | CYP2C19 (0.67) | CYP2C19POLBTDP1SLC1A3SLC1A2 | |
| SCHEMBL7401586 | 0.73 | SLC7A5 (0.38) | CYP2C19POLBAPEX1SLC1A2ALDH1A1 | |
| SCHEMBL7363028 | 0.73 | SLC6A2 (0.41) | HSD11B1ALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL7367030 | 0.73 | PTGER1 (0.42) | POLBTDP1ALDH1A1KMT2ARAB9A | |
| SCHEMBL7363860 | 0.73 | PTGER1 (0.42) | CYP2C19ALDH1A1 | |
| SCHEMBL7361069 | 0.73 | CYP1A2 (0.45) | CYP2C19APEX1SLC1A2ALDH1A1CYP3A4 | |
| SCHEMBL7361669 | 0.72 | SMN1; SMN2 (0.42) | CYP2C19L3MBTL1TDP1APEX1SLC1A2 | |
| SCHEMBL7399248 | 0.72 | HSD17B10 (0.45) | CYP2C19APEX1SLC1A2ALDH1A1KMT2A | |
| SCHEMBL7364664 | 0.72 | RARB (0.38) | CYP2C19APEX1SLC1A2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |